Labor académica
TESIS DE DOCTORADO
Tesistas | Titulo | Programa | Año |
Nadia Guajardo | Evaluación de la selectividad de lipasas inmovilizadas en reacciones de síntesis asimétricas. Profesora Guía: Lorena Wilson; Profesora Co-Guía: Zaida Cabrera. | Doctorado en Ciencias de la Ingeniería con mención en Ingeniería Bioquímica | 2014 |
PROYECTOS
Proyectos con financiamiento Externo
Asymmetric synthesis of chiral compounds at high concentrations of substrate catalyzed by immobilized and stabilized enzymes. Investigador Principal. | FONDECYT 1130981 | 2013-2015 | |
Consolidación de Naturalis como puente para la aplicación del conocimiento científico desde Chile para el mundo. Subproyecto Nº5 del Proyecto “Fosfolipidos estructurados para la prevención y tratamiento de dislipidemias y cáncer” Asesor Técnico. | CORFO INNOVA 12CTI-16838 | 2013-2015 | |
Desarrollo de un agente biológico para su aplicación industrial en el proceso de blanqueamiento de la pulpa de celulosa. Ingeniero Investigador | INNOVA 10IEI-7152 | 2010-2012 | |
Reacciones asimétricas catalizadas por enzimas inmovilizadas y estabilizadas. Investigador Responsable. | FONDECYT 11090321 | 2009-2012 |
PUBLICACIONES
Publicaciones en revistas
- Guajardo, N.; Bernal, C.; Wilson, L.; Cabrera, Z., Asymmetric hydrolysis of dimethyl-3-phenylglutarate in sequential batch reactor operation catalyzed by immobilized Geobacillus thermocatenulatus lipase.; Catalysis Today, En prensa DOI: 10.1016/j.cattod.2014.12.039., 2015
- Palomo, J.M., Cabrera, Z., Enzymatic Desymmetrization of Prochiral Molecules.; Current Organic Synthesis, 9, 791-805, 2012
- Cabrera, Z.; Palomo, J.M., Enantioselective Desymmetrization of prochiral diesters catalyzed by immobilized Rhizopus oryzae lipase.; Tetrahedron: Asymmetry, 22, 2080-2084, 2011
- Cabrera, Z., Palomo, J.M.
, Enantioselective Desymmetrization of prochiral diesters catalyzed by immobilized Rhizopus oryzae lipase. ; Tetrahedron: Asymmetry, doi:10.1016/j.tetasy 2011.11.012 , 2011 - Cabrera, Z., Gutarra, M., Guisan, J.M., Palomo, J.M. , Highly enantioselective biocatalysts by coating immobilized lipases with Polyethyleneimine. ; Catalysis Communications, , 11, 964–967. , 2010
- Cabrera, Z.; Fernandez-Lorente, G.; Fernandez-Lafuente, R.; Palomo, J. M.; Guisán, J. M.
, Novozym 435 displays very different selectivity compared to lipase from Candida antarctica B adsorbed on other hydrophobic supports; Journal of Molecular Catalysis B: Enzimatic,, 57, 171-176. , 2009 - Fernández-Lorente, G., Cabrera, Z., Godoy, C., Fernández-Lafuente, R., Palomo, J. M., Guisán, J.M. , Interfacially activated Lipases against hydrophobic supports: effect of the support nature on the biocatalytic properties.; Process Biochemistry, , 43; 1061-1067, 2008
- Cabrera, Z., Fernández-Lorente, G., Fernández-Lafuente, R., Palomo, J. M., Guisán, J.M.,Asymmetric hydrolysis of dimethyl 3-phenylglutarate catalyzed by Lecitase Ultra® Effect of the immobilization protocol on its catalytic properties; Enzyme and Microbial Technology, 43; 531-536. , 2008
- Cabrera, Z., Fernández-Lorente, G., Fernández-Lafuente, R., Palomo, J. M., Guisán, J.M.,Enhancement of Novozyme-435 catalytic properties by physical or chemical modification.; Process Biochemistry, , 44, 226-231. , 2008
- Cabrera, Z., Palomo, J.M., Fernández-Lorente, G., Guisán, J. M., Fernández-Lafuente, R. ,Partial and Enantioselective Hydrolysis of diethyl phenylmalonate by immobilized preparations of lipase from Thermomyces lanuginosa.; Enzyme and Microbial technology, 40, 1280-1285. , 2007
- Cabrera, Z., Lopez-Gallego, F., Fernández-Lorente, G., Palomo, J.M., Montes, T., Grazu, V., Guisán, J. M., Fernández-Lafuente, R. , Asymmetric hydrolysis of dimethyl phenylmalonate by immobilized preparations of Penicillin G. acylase from E. coli.; Enzyme and Microbial Technology,, 40, 997-1000. , 2007
- Fernández-Lorente, G., Palomo, J.M., Cabrera, Z., Guisán, J.M., Fernandez-Lafuente, R. ,Specificity enhancement towards hydrophobic substrates by immobilization of lipases by interfacial activation on hydrophobic supports.; Enzyme and Microbial Technology, , 41, 565-569., 2007
- Illanes, A., Cabrera, Z., Wilson, L., Aguirre, C., Synthesis of cephalexin in ethylene glycol with glyoxyl-agarose immobilised penicillin Acylase: temperature and pH optimisation; Process Biochemistry, 39,111-117, 2003
- Rocha, J., Vega, D., Cabrera, Z., Bolivar, J. M., Fernandez-Lafuente, R., Berenguer, J., Guisán, J.M. , Purification, immobilization and stabilization of a highly enantioselective alcohol dehydrogenase from Thermus thermophilus HB27 cloned in E. coli.; Process Biochemistry,, 44, 1004-1012, 2009
- Fernández-Lorente, G., Palomo, J.M., Cabrera, Z., Fernández-Lafuente, R, Guisán, J.M. ,Improved catalytic properties of immobilized lipases by the presence of very low concentrations of detergents in the reaction medium.; Biotechnology Bioengineering, , 97, 242-250., 2007
- Illanes, A., Wilson, L., Altamirano, C., Cabrera, Z., Alvarez, L., Aguirre, C. , Production of cephalexin in organic medium at high substrate concentrations with CLEA of penicillin acylase and PGA-450.; Enzyme and Microbial Technology, , 40 195–203., 2007
- Fernández-Lorente, G., Palomo, J. M., Mateo, C., Munilla, R., Ortiz, C., Cabrera, Z., Guisán, J.M., Fernández-Lafuente, R., Glutaraldehyde crosslinking of lipases adsorbed on aminated supports in the presence of detergents leads to improved performance.; Biomacromolecules, 7, 2610-2615., 2006